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This albumin binding creates a large circulating reservoir of the peptide that is released slowly over time, yielding a half-life of approximately one week in human research subjects and making once-weekly subcutaneous administration pharmacokinetically viable
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The anxiolytic effect of Selank has been demonstrated in multiple rodent behavioral paradigms: elevated plus maze (increased open arm time), Vogel conflict test (increased suppressed drinking), and social interaction test (increased social contact time)
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