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M1 macrophages amplify inflammation, eliminate pathogens, and inflict tissue damage by secreting a repertoire of proinflammatory mediators, whereas M2 macrophages are involved mainly in tissue repair (fibrosis and neovascularization) (186)
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Also selective deficiency of peroxisomes in oligodendrocytes leads to early axonal loss and neuroinflammation in the absence of demyelination [60]
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