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[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Rose P., Moore P.K., Zhu Y.Z

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Future studies of NAC in PD would require much larger sample sizes likely necessitating multiple sites and must take into consideration the route of administration, dosage regimen, duration of therapy, and selection of an optimal biomarker and methods for monitoring.Further, a rigorous data and safety monitoring plan should be part of any study design, so that adverse effects can be quickly identified and managed