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NaBPC157 (10 ⁇ g or 10 ng/kg i.p.) has a prophylactic effect (applied either 1 hour before, or simultaneously with 96% ethanol (1 ml/rat, i.g.)) and a salutary effect (applied 1 hour after ethanol at the maximum of the lesion's development)

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Important limitations include the failure to replicate rodent cardiac findings in a pig model (Stark et al., 2016), limited long-term safety data beyond 14 days of human dosing, and the absence of large-scale Phase III trials for systemic indications

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