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Research published in the British Journal of Pharmacology demonstrated that molecular conjugation of B12 (specifically the corrin ring structure found in cyanocobalamin) with GLP-1 receptor agonists produced a compound that was not as readily absorbed into the brainstem areas responsible for triggering nausea
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The hypothesis was that the hormone behaves as a pro-hormone, with different regions responsible for different effects, and that the C-terminal region was the lipolytic one
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