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The OPTIUUM trial evaluated the efficacy of ponesimod in comparison to teriflunomide 14 mg daily in patients with relapsing multiple sclerosis, an EDSS of 5.5 or less, and active disease evidenced by one or more relapses within 12 months, two or more relapses within 24 months, or one or more Gd+ lesions on MRI within 6 months (57)
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