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Oral BPC-157 Dosing Protocol For Gut Healing (IBS, Leaky Gut, Ulcers) Dose: 250–500 mcg, taken 2x daily Timing: On an empty stomach — 30 minutes before meals or 2 hours after Duration: 4–8 weeks minimum for gut healing protocols Notes: Start at 250 mcg 2x/day for the first week, then increase to 500 mcg 2x/day if tolerated well For General Maintenance / Prevention Dose: 250 mcg once daily Timing: Morning, empty stomach Duration: Can be run for longer periods (8–12 weeks) at maintenance dose Injectable BPC-157 Dosing Protocol For Acute Injuries Dose: 250–500 mcg, 1–2x daily Injection site: SubQ, as close to the injury as possible Duration: 4–6 weeks (many injuries resolve within 2–3 weeks) For Chronic / Overuse Injuries Dose: 500 mcg, 1x daily Injection site: SubQ near injury, rotating slightly each day Duration: 6–8 weeks, with potential re-evaluation at 4 weeks How to Reconstitute BPC-157 for Injection If you choose the injectable route, reconstitution is a critical skill

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found that CD38 triggers NLRP3 inflammasome activation in vascular smooth muscle cells under diabetic conditions via Ca 2+ release mediated by cADPR