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Selective inactivation of the signal transduction adapter p62/Sqstm1 in adipocytes, secretion of osteopontin, and upregulation of CPT1A expression drive prostate cancer invasion [97]
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It is to be noted that the BCKDH reaction is essentially irreversible in mammalian cells such that BCKA synthesis depends on essential amino acids, BCAAs, due to the lack of BCKAs de novo synthetases
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