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ET Treatment Protects Against Rotenone‐Induced Neurotoxicity in Human LRRK2 G2019S‐Derived Neuronal Cultures Containing DA Neurons To assess the neuroprotective potential of ET in a model that is even closer to human PD, we generated human neuronal cultures containing DA neurons bearing the LRRK2 G2019S mutation from patient‐derived iPSCs using the protocol described by Laperle et al
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These molecules are essential for various cellular processes, such as differentiation, proliferation, autophagy, necrosis, and programmed cell death, by acting as signaling molecules or modulating transcription factor activity [30]
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