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Compared to normal tissue, GLO-1 was significantly upregulated in 28 tumors, including GBM (Tumor: 6.73 ± 0.48, Normal: 5.37 ± 1.31, p = 6.7e−75), GBMLGG (Tumor: 6.58 ± 0.41, Normal: 5.37 ± 1.31, p = 8.5e−216), LGG (Tumor: 6.53 ± 0.37, Normal: 5.37 ± 1.31, p = 3.7e−178), BRCA (Tumor: 6.83 ± 0.68, Normal: 5.37 ± 1.31, p = 3.7e−179), EGFR (Tumor: 6.83 ± 0.68, Normal: 5.37 ± 1.31, p = 3.7e−179), CESC (Tumor: 6.44 ± 0.63, Normal: 5.91 ± 0.21, p = 1.2e−4), LUAD (Tumor: 6.49 ± 0.68, Normal: 5.87 ± 0.93, p = 3.5e−42), ESCA (Tumor: 6.78 ± 0.62, Normal: 5.25 ± 1.26, p = 6.3e−84), STES (Tumor: 6.44 ± 0.68, Normal: 5.13 ± 1.38, p = 3.6e−165), COAD (Tumor: 6.40 ± 0.52, Normal: 4.99 ± 1.67, p = 2.6e−90), COADREAD (Tumor: 6.43 ± 0.55, Normal: 5.01 ± 1.66, p = 1.9e−102), PRAD (Tumor: 7.81 ± 0.90, Normal: 6.52 ± 1.03, p = 4.7e−34), STAD (Tumor: 6.29 ± 0.65, Normal: 4.75 ± 1.64, p = 6.8e−64), HNSC (Tumor: 6.49 ± 0.60, Normal: 5.72 ± 0.54, p = 9.7e−15), LUSC (Tumor: 6.52 ± 0.66, Normal: 5.87 ± 0.93, p = 9.2e−48), LIHC (Tumor: 5.86 ± 0.76, Normal: 4.87 ± 0.60, p = 9.8e−38), WT (Tumor: 7.21 ± 0.38, Normal: 6.07 ± 1.49, p = 3.5e−35), SKCM (Tumor: 6.14 ± 0.83, Normal: 5.78 ± 0.39, p = 4.1e−11), BLCA (Tumor: 6.13 ± 0.74, Normal: 5.78 ± 0.33, p = 1.3e−3), THCA (Tumor: 5.64 ± 0.43, Normal: 5.29 ± 0.92, p = 7.8e−28), READ (Tumor: 6.50 ± 0.62, Normal: 6.02 ± 0.34, p = 4.8e−3), OV (Tumor: 6.59 ± 1.08, Normal: 6.11 ± 0.26, p = 5.6e−14), PAAD (Tumor: 5.58 ± 0.46, Normal: 3.62 ± 1.58, p = 1.0e−53), TGCT (Tumor: 6.01 ± 0.89, Normal: 4.47 ± 0.63, p = 1.3e−37), and UCS (Tumor: 6.72 ± 0.60, Normal: 5.74 ± 0.29, p = 5.2e-18)

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the facilitation of growth and development