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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Blackwell T.K., Steinbaugh M.J., Hourihan J.M., Ewald C.Y., Isik M
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Inhibit osteoclast activation and differentiation, reduce bone resorption Block osteoclast differentiation signal RANKL/RANK/OPG pathway: AOD 9604 downregulates the expression of RANKL (a key factor in osteoclast differentiation) and upregulates the expression of OPG (a RANKL antagonist), reducing the RANKL/OPG ratio by 50-60% and blocking the differentiation of osteoclast precursors into mature osteoclasts
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