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A drug can not generally have an oral bioavailability value higher than its value for f H , and oral bioavailability can equal f H only when all of the drug escapes from the GI tract and is able to enter the portal circulation (i.e
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Subacute combined degeneration of the spinal cord , a serious complication of untreated B12 deficiency described in NHS and British Society for Haematology guidance, affects both the dorsal columns and corticospinal tracts
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