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Numerous evidences highlighted the influence of both male and female sex hormones on neural circuit development, sex-specific behaviors and sexual differentiation of mammalian brain from the fetal-neonatal period to puberty and adult life (reviewed in Hines, Interestingly, the group of Shah showed that the conversion of testosterone to estradiol by the enzyme aromatase is necessary during the perinatal period for the expression of masculine sex behavior in the adult, while the absence of testosterone and estrogen is necessary for normal development of female brains (Wu et al., 2009)