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Meanwhile, HIF-1α can inhibit chondrocyte catabolism and maintain the dynamic balance of articular cartilage matrix by regulating NF-κB signalling and limiting the expression of matrix metalloproteinase (MMP)-13 (58)

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No trial reported on clinical signs and symptoms of vitamin B 12 deficiency, health-related quality of life, or acceptability of the treatment scheme Orally taken vitamin B 12 showed lower treatment-associated costs than intramuscular vitamin B 12 in one trial