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In Fmr1 KO mice these agents showed improvement of several FXS features, including better behavioral abilities, restoration of normal levels of dendritic spines and reduction in protein synthesis (69)
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This neuroinjury is mediated by the disruption of cAMP-response element-binding protein (CREB) activation and brain-derived neurotrophic factor (BDNF) expression (Gan et al., 2025)
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