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The histone methylation patterns on the cis-acting elements of Foxp3 also regulate Treg cell differentiation, including H3K4me1 at the CNS3, promoter, and 3’UTR of Foxp3 , as well as H3K4me3 at its promoter to facilitate gene expression [74–76]
Oliv and Ash
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These tend to improve over time as the body adjusts to the medication
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