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Consequently, plants have developed a sophisticated network of defense systems to protect themselves from pathogen incursions and the development of diseases ( The GSH itself is created from amino acids, including glutamate, L-cysteine, and glycine, through two ATP-dependent enzymatic reactions mediated by γ-glutamylcysteine synthetase (γ-ECS or also known as GSH1) and GSH synthetase (GS or also named GSH2) ( Figure 1 )

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In astrocytes, MPTP has shown different (and sometimes contradictory) effects according to the experimental evidence collected in cellular and animal models