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Pooled, purified, PtX-treated, and washed, cells were incubated for 10 min at room temperature with 1.5 ml 3 H-SP solution in ES (1.8 MBq

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Early stage atherosclerosis may involve normal and perhaps increased LAL activity leading to cytosolic lipid droplet accumulation, whereas later stages of atherosclerosis may have an acquired dysfunction in LAL hydrolytic activity leading to lysosomal lipid sequestration