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In recent years, the term metabolic dysfunction-associated steatotic liver disease (MASLD) has been proposed to replace NAFLD, emphasizing its role as a hepatic manifestation of broader systemic metabolic dysregulation [34]
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Additionally, some studies, such as those involving oral doses of PBF-677 in healthy volunteers, employed dose-escalation methodologies to determine the maximum tolerated dose while closely monitoring for potential side effects (NCT02639975)
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