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Moreover, various transcription factors such as specificity protein 1 (SP1), activator protein 1 (AP-1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and GATA1 were reported to play an important role in the regulation of GSTP1 expression ( Figure 1
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The decline in GSH synthesis associated with aging combined with an increase in body burden of chemicals over a lifespan contribute to age-related hypomethylation
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