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Literature studies have shown that polypeptides can regulate basal cellular functions at molecular level, such as cytokine/chemokine release and cell proliferation [327]
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Although in some studies, including ours, the rs1799983*G allele was more prevalent in the obese cohort than controls that differs from other studies in which the rs1799983*T allele was the risky one, previous reports have indicated interethnic differences in rs1799983 distribution and evidence for linkage disequilibrium with other SNPs exists among populations [86,87]
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