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Lifestyle Changes That Make the Biggest Difference Moisture-wicking shorts under dresses and skirts — the single most effective friction reducer for this area Anti-chafe balm before walks or exercise — creates a temporary friction barrier that reduces daily pigmentation triggers Looser-fitting trousers — tight denim and leggings create constant inward pressure that worsens the condition Stay hydrated — dry skin has less natural lubrication and experiences more friction damage per step When to See a Doctor Most inner thigh darkening is cosmetic and responds to topical treatment

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The Bottom Line The most-researched peptides, including BPC-157, thymosin beta-4, GHK-Cu, and IGF-1, share a pattern