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FOXO4-p53 competition → displacement of p53 from nuclear sequestration Mitochondrial p53 relocation → apoptosis in senescent cells Senescence-restricted complex → viable cells largely unaffected D-retro-inverso design → side-chain topology preserved, proteases evaded Core Areas of Scientific Investigation Senolytic Research: FOXO4-DRI is a reference compound for selectively removing senescent cells in culture and rodent models
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