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Other causes include stenotic lesions (aortic and pulmonary stenosis, coarctation of the aorta, tetralogy of Fallot) or relative pulmonary stenosis due to increased flow from an ASD Crescendo decrescendo murmur b) Holosystolic (regurgitant) murmurs start at the beginning of S1 (pulse) and continue to S2
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Biased agonism describes how different ligands, upon binding to the same receptor, can preferentially stabilize distinct receptor conformations, thereby selectively activating specific downstream signaling pathways (e.g., Gαs-cAMP vs
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