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S -Adenosylmethionine synthetase S -Adenosylmethionine synthetase (EC 2.5.1.6), also known as methionine adenosyltransferase ( MAT ), is an enzyme that creates S -adenosylmethionine (also known as AdoMet, SAM or SAMe) by reacting methionine (a non-polar amino acid) and ATP (the basic currency of energy)
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