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Analyses within individual families showed that heterozygosity for IGFALS mutations resulted in approximately 1.0 SD height loss in comparison with wild-type, whereas homozygosity or compound heterozygosity resulted in a further loss of 1.0–1.5 SD, suggestive of a gene-dosage effect

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Because phentermine increases norepinephrine, dopamine, and serotonin, some patients experience anxiety or irritability — particularly in the first few weeks as the body adjusts

and the appearance of expression lines is diminished