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Viral envelope proteins could also trigger abnormal immune response, dysregulate type-1 IFN synthesis, increase NETosis and cause organ injury via microthrombi formation 187
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Mechanism-informed strategies therefore target sources and nodes rather than applying blanket antioxidants: source-targeted ROS amplification inside tumors (e.g., radiotherapy or certain chemotherapies combined with ferroptosis inducers and microenvironmental iron loading to accelerate lipid peroxidation) can overwhelm malignant buffers, while node inhibition (selective NOX isoforms, FSP1/CoQ rescue circuits, or lipid-peroxidation repair pathways) can re-sensitize resistant clones (Jiang et al
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