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As discussed in greater detail in Section 2.6 of this review, the energy-producing cellular processes such as the mitochondrial tricarboxylic acid cycle (TCA) cycle and the electron transport chain (ETC) create ROS that have the potential to be toxic to cells if not regulated properly by antioxidant defense mechanisms such as GPX4 [125,126]
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The supplements on this list with the greatest perceived impact on a population level and for which there is biologically plausible rationale for their use in PD should be considered for evaluation in prospective intervention studies
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