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In an in vivo mouse calvarial osteolysis model, quercetin was found to inhibit titanium particle-induced osteolysis by preventing the formation of osteoclasts and the expression of ERS-related genes [176]
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Similarly, resveratrol easily crosses the blood-brain barrier due to its lipophilic structure, participates in astrocyte proliferation and activation, maintains T-lymphocyte mediated adaptive immunity, and exhibits the anti-inflammation effect, and reduces stimulation of the central nervous system [89]
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