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303 Arginase 2 (Arg 2) is a regulator of activated T cells, and Arg 2-deficient or Arg2 −/− CD8 + T cells exhibit enhanced cytotoxicity and synergistic effect with anti-PD-1 antibody in inhibiting tumor growth
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In contrast to expectations, overexpression of the mitochondrial 2-oxoglutarate carrier markedly increased cell death from exposure to the nephrotoxic chemotherapeutic drug cisplatin (CDDP)
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