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[12] GH release stimulates protein synthesis and nitrogen retention, which is the rationale for investigating GH secretagogues in catabolic states such as post-surgical recovery, critical illness, prolonged bedrest, and age-related muscle wasting (sarcopenia)
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Such discouraging findings have prompted research efforts directed at the development of small molecules configured to penetrate the blood-brain-barrier (BBB) and stimulate brain neurotrophins
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