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Phenylpropanoids Schizandrin B and nordihydroguaiaretic acid have inhibitory effects against cisplatin-induced nephrotoxicity, and their renoprotective mechanisms are associated with oxidative stress, inflammatory response, and apoptosis [120, 121]
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However, the drug combination did not exhibit any enhanced effect on cell thermogenesis and these proteins in vitro , whereas combination of norepinephrine and metformin-induced an additive upregulation of mitochondrial function-related proteins
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