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However, the question remains contentious as to whether the observed decline in GFR is attributable to the natural aging process or to concurrent comorbidities (Zhou et al., 2008b)
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Studies have shown that evodiamine (which increases acetylation levels by approximately 3–4-fold at a concentration of 5 μM) and paclitaxel (which induces peak acetylation within 30 min at 33 nM) both enhance NLRP3 inflammasome activation and subsequent pyroptosis by specifically promoting acetylation at lysine 40 (K40) of α-tubulin—a process dependent on the acetyltransferase MEC-17—thereby revealing their mechanisms of action in cancer therapy [283, 284]
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