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2 Ferroptosis in OA: molecular mechanisms and pathological significance 2.1 Ferroptosis in OA pathogenesis: emerging connections Characterized by iron dysregulation and lipid peroxide overload, ferroptosis—originally triggered by the small molecule erastin—was formally defined in 2012 by Dixon’s seminal work (Yang J
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34 The painful pathological state of gout is mainly induced by hyperuricemia with the concentration of more than 6.8 mg/dL under physiological conditions (37 ◦C, pH 7.4)
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