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During ASP treatment, none of the mice showed abnormal activity, and no abnormalities were found in weekly body weight or blood glucose assessments (Supplementary Figure S1)

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Activation of these AREs stimulates the transcription of protein targets and other anabolic systems, such as the local production of IGF-1 which is related to muscle protein accretion through a decrease in IGFBP-4 mRNA concentration coupled with an increase in IGF-1 mRNA (Bamman et al., 2010) (see IGF-1 section)