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Changes in morbid adipose tissue in endocrine characteristics could decrease adiponectin secretion, which is an insulin enhancer ( Metabolomics revealed that APS could strengthen ISI by upregulating the mi-RNA transducer of ErbB2.2, TMEM100, and the ubiquitin-specific proteases (USP15) ( 2.3 Oxidative Stress, Endoplasmic Reticulum, and Mitochondrial Injury In NASH patients, studies revealed a positive relationship between OS levels and IR severity, fat degeneration, inflammatory response, and fibrosis (Tariq et al., 2014)
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2020;324(20):2038-20 PubMed Almeida CED, Carvalho LR, Andrade CVC, Nascimento PD Jr, Barros GAM, Modolo NSP
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