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Studies using HFD-induced obesity models have indicated that obesity can induce an immunosuppressive tumor microenvironment characterized by the accumulation of myeloid-derived suppressor cells (MDSCs) [122], macrophages [123, 124] and neutrophils [125, 126] and the dysfunction of dendritic cells [127], natural killer (NK) cells [128] and T cells [74, 129, 130]
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