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It is a dimeric complex composed of: The calcitonin receptor (CTR) , a GPCR The RAMP protein (Receptor Activity Modifying Protein), 1, 2 or 3 Depending on the type of RAMP, three different amylin receptors arise: AMY1 : CTR + RAMP1, primarily in the CNS (area postrema, hypothalamus) AMY2 : CTR + RAMP2, peripheral tissues AMY3 : CTR + RAMP3, bone tissue, some CNS Cagrilintide activates all three amylin receptors , but the primary therapeutic effect is via AMY1 in the area postrema (brainstem, where nausea and satiety signals are processed)
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High Ferritin – Iron Overload/Toxicity As a side rabbit hole, while I had been struggling with low ferritin that was discovered in 2011 and resolved in 2017 (it also flared up in 2020, then again in 2022), ironically, my husband had iron overload that was diagnosed in 2018, and it resolved in 2021 due to some extreme lifestyle changes
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