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Furthermore, in APP/PS1 mice, chronic ergothioneine administration improved cognitive performance, reduced Aβ deposition and neuronal damage, attenuated microglial activation and TNF-α levels, and reshaped the gut microbiota alongside short-chain fatty acid profiles and sphingo-/glycerophospholipid metabolism, supporting a gut–brain–lipid axis for this mushroom-derived metabolite [109]
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