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The expression of CD73 and CD39 is high in gastric cancer cells and tumor-associated Tregs, and activation of adenosine signaling enhances the stem cell properties of GC, promoting tumor invasion and metastasis (111)
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The oral route illustrates the point at its sharpest: it has the longest terminal half-life of the three, 14.8 hours, and never reached the inhibitory concentration at all
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