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PMID: 36329515 J Exp Clin Cancer Res Pyrotinib targeted EGFR/GRP78 mediated cell apoptosis in high EGFR gene copy number gastric cancer
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7.6 Theoretical human equivalent doses estimates In the current absence of human clinical dose data, theoretical human equivalent doses (HEDs) can be estimated from animal model effective doses using the FDA-recommended interspecies allometric scaling method: HED (mg/kg) = Animal dose (mg/kg) Γ (Animal Km Γ· Human Km), where Km correction factors are: mouse = 3, rat = 6, human = 37 (40)
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