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Collectively, it could be deduced that exogenous H 2 S reversed doxorubicin resistance of HCC through inhibiting the levels of ABCA1 and ABCG8 by inhibiting the binding of LXRα/RXRβ with ABCG8 and ABCA1 genes promoter via suppression of the heterodimer formation between RXRβ and LXRα, which needed to be further confirmed (Stokes et al., 2018)
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Brain magnetic resonance imaging and upper gastrointestinal endoscopy may also be indicated in certain circumstances
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