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N-glycans likely mediate inter-domain interactions at the ATD-LBD interface It has been shown that the composition, content, and length of N-glycans can be variable for iGluRs depending on the context of their expression

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Volkova A et al., 2016 [PubMed] Key Areas of Research: Molecular Tuftsin receptor binding characterization, GABAergic gene expression profiling, peptide structural stability assays in biological matrices, angiotensin-converting enzyme interaction mapping, enzymatic cleavage resistance characterization Cellular / Neurochemical GABAergic signaling pathway characterization, inhibitory neurotransmission parameter assessment, neuroblastoma cell line gene expression profiling, GABA₂ receptor interaction modeling, anxiolytic-relevant receptor system characterization in preclinical settings Systemic (Preclinical) Behavioral parameter measurement in anxiety-relevant preclinical models, cytokine pathway modulation monitoring, neuroimmune axis interaction characterization, inhibitory signaling system profiling in controlled investigational settings Together, these findings suggest broad experimental potential for Selank across GABAergic neurotransmission, neuroimmune signaling, and preclinical anxiety-model research pathways