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In Hartnup disorder, tryptophan absorption is impaired and in malignant carcinoid syndrome tryptophan metabolism is altered resulting in excess serotonin synthesis

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While ghrelin remains as of today the only known peripheral gut hormone that is capable of stimulating food intake and body weight gain, a myriad of studies have subsequently revealed that ghrelin is a hormone with a vast spectrum of physiological actions that go far beyond its initial classification as a hunger hormone (Figure 1