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This stage is also called lipo-lymphedema and involves: Significant swelling that may now include the feet and hands Hardened, fibrotic tissue Increased risk of skin infections Severe mobility impairment Substantial impact on quality of life Stage 4 requires comprehensive treatment addressing both the lipedema and lymphedema components

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Meanwhile, the scatter plot of certain different pairwise correlations between the HDP and normal pregnancy groups are presented in Figure 6D