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Here, we investigated different transport mechanisms involved in the BBB permeation of small molecules to identify features that predict positive BBB transport
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In humans receiving ellagitannin-rich pomegranate extract (1 g), peak plasma concentrations of urolithin A glucuronide reached over 80-fold the C max of ellagic acid (2.47 μM compared to 0.02–0.061 μM), indicative of greater bioavailability of the microbial metabolite (Seeram et al., 2008)
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