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PFPs organize into supramolecular transmembrane complexes that perforate membranes through a multistep process involving membrane insertion, protein oligomerization, and finally pore formation

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It is important to note that organelle-containing erythroid lineage cells can undergo intrinsic [37] and extrinsic apoptosis [38], receptor-interacting serine/threonine-protein kinase 1 (RIPK1)-dependent necroptosis [39], or iron-driven ferroptosis [40]