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This review will focus on the reservoirs and mechanisms of pathogenic yeast infections, the challenges faced upon infection and the hurdles that must be overcome to combat antifungal drug resistance
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Specifically, the upregulation of the Nrf2 pathway triggers the production of phase II detoxifying/antioxidant enzymes, such as HO-1 and GSTa, while the downregulation of the TLR2/MyD88/NF-κB pathway results in a decreased production of pro-inflammatory cytokines, including IL-1β, IL-8, and TNF-α
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