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An alteration in the phosphorylation pattern, such as an increase in tyrosine phosphorylation, which results from pathological conditions, such as inflammation or elevated ROS, can alter the protein–protein interactions of occludin with ZO-1, ZO-2, and ZO-3, and thereby alter the membrane integrity 75
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IV delivers systemic antioxidant benefits and is more common for whole-body effects, while IM offers localised benefits and is sometimes used for maintenance dosing
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