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The N-acetyl and C-terminal amide modifications enhance the peptide’s resistance to aminopeptidase and carboxypeptidase degradation, extending its biological half-life compared to unmodified Selank

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In one case (MOTS-c), the peptide is being reviewed for both the medical conditions for which it is associated as well as its effect on well-being (i.e., metabolism and longevity): TB-500: wound healing Semax: cerebral ischemia, migraine, trigeminal neuralgia MOTS-c: insulin resistance, obesity, osteoporosis, vascular calcification, muscle/fat metabolism, longevity KPV: wound healing, inflammatory conditions Epitalon: insomnia Emideltide: opioid withdrawal, chronic insomnia, narcolepsy BPC-157: ulcerative colitis FDA's Initial Assessment and Recommendations The advisory committee will provide its recommendations about listing the individual peptides on the 503A list at the meeting to be held on July 23 and July 24